Cruz was struck by a changeup from Texas' Brandon Mann and limped to the dugout with the help of two staff members. Seattle says X-rays were negative and that Cruz will be re-evaluated Wednesday.
It was the second time Cruz was hit by a pitch in the game. Starter Mike Minor plunked him in the third inning.
Cruz was making his 358th start at designated hitter for Seattle, which broke a tie with Ken Phelps for most in franchise history.
Seattle lost star Robinson Cano to an 80-game suspension for a violation of baseball's drug agreement earlier in the day.